What is Ubiquinol?

Ubiquinol (“you-bik-win-all”) and Ubiquinone are vitamin-like substances produced naturally in the body. They are two different forms of the same vital nutrient (Co-Enzyme Q10 or CoQ10), with each performing distinct functions within the body. One of the key differences between these forms is that ubiquinol acts as a potent antioxidant to protect cells from free radical damage. Despite these differences in function, ubiquinone and ubiquinol are indispensable partners in creating the cellular energy your body runs on.

CoQ10 can shift, thousands of times a second, between the ubiquinol and ubiquinone forms. This process of converting ubiquinone to ubiquinol and back again is a key aspect of cellular energy production. This transformation process helps create the cellular energy your heart and other vital organs need to maintain proper function.¹However, as you age, it can become more difficult and less efficient for your body to perform this conversion.

A Kaneka Ubiquinol^® supplement is the antioxidant form of CoQ10 that your body can immediately use for antioxidant protection without any conversion.² Taking a Kaneka Ubiquinol^® supplement can offer several key health benefits – read below to find out more!

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Key Benefits of Ubiquinol

Ubiquinol Supports Heart Health*

Ubiquinol promotes heart health by helping to provide the cellular energy needed to power the heart. Naturally occurring ubiquinol is critical in the production of ATP, the body’s primary fuel.¹ This fuel is used for three basic yet critical heart functions:

Contraction – to keep the heart pumping consistently
Relaxation – to allow the heart to rest between beats
Molecular Synthesis – to maintain heart health by building important cellular components.*

Your heart is one of the most energy-demanding organs in your body. Your heart must generate large amounts of ATP (or cellular energy) to pump blood to your arteries, and it requires even more energy to relax the contracted muscle. Since your heart is constantly contracting and relaxing, it must generate ATP constantly and consistently. Maintaining enough ATP in the “energy pool” is essential to the heart’s proper function.

For some adults, taking a daily Kaneka Ubiquinol^® supplement can help maintain the cellular “energy pool” by maintaining a healthy ratio of ubiquinone and ubiquinol.

Ubiquinol Supports Healthy Aging

As we age, the body’s ability to convert CoQ10 into ubiquinol declines, which can lead to decreased levels of ubiquinol and increased oxidative stress.³ Oxidative stress is caused by an imbalance or excess of free radicals and is associated with premature aging.

Exciting research has shown that Kaneka Ubiquinol^® helps protect against premature aging associated with oxidative stress, which is a key factor for healthy aging.^4,5,6

As a powerful antioxidant, Ubiquinol supplementation helps protect proteins, DNA, and cells from oxidation caused by free radicals.⁶

Ubiquinol Supports Men & Women’s Reproductive Health

Research shows that Ubiquinol can support reproductive health for both men and women. Oxidative stress can damage reproductive cells.^7,8 For women, supplementation with Kaneka Ubiquinol^® supports the cellular energy and mitochondrial integrity required for healthy egg function.

For men, research demonstrates positive effects on sperm health with daily supplementation of 150 mg or 200mg/day of Kaneka Ubiquinol^® over the course of 6 months. In one study, there was a statistically significant increase in sperm motility, morphology, and total sperm count compared to baseline.⁹ In another study focused on men with normal sperm counts, participants who took 200 mg of Ubiquinol daily for 6 months experienced statistically significant increases in sperm motility and sperm morphology.

It’s important to note that taking Kaneka Ubiquinol^® during your preconception journey can assist your body in maintaining a healthy antioxidant balance and ubiquinol to CoQ10 ratio which supports reproductive health. However, for those taking Kaneka Ubiquinol^® for heart health or healthy aging benefits, ubiquinol will not increase the likelihood of pregnancy if effective contraception measures are followed.

Ubiquinol Replenishes CoQ10 Levels Depleted by Cholesterol-Lowering Medications (Statins)

Cholesterol is a fatty compound found in your blood and an important component of human health. However, high levels of LDL cholesterol have been linked with an increased risk of heart disease. To lower LDL cholesterol levels, a statin medication may be prescribed by your doctor. Statin medications limit the body’s production of cholesterol. In the process, they also reduce the body’s natural production of ubiquinol.¹¹ Taking a Ubiquinol supplement each day is an excellent way of replenishing ubiquinol levels that may be reduced by cholesterol medications.*^12,13

Kaneka Ubiquinol® vs. Conventional CoQ10

When choosing a CoQ10 supplement, it’s important to understand whether Kaneka Ubiquinol^®, the antioxidant form of CoQ10, or conventional CoQ10 would better suit your needs. Ubiquinol may have a higher price point, but research demonstrates that Kaneka Ubiquinol^® has 2x greater absorption than conventional CoQ10.¹⁴ Also, in a clinical study, Ubiquinol levels increased by approximately eight times compared to baseline in healthy adults taking 200 mg of Kaneka Ubiquinol^® daily for at least 30 days.¹⁵

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Why is Ubiquinol Better Than Conventional CoQ10?

Benefit	Ubiquinol	Conventional CoQ10
Required for 95% of your cellular energy production*^{12 13 15 16 17 18}
Superior bioavailability^{10 12 15}
Optimally replenishes Ubiquinol in your body to provide antioxidant protection and promote cellular energy^10-14
Predominant form of CoQ10 in a healthy body^3,4,13

Learn More

Martini FH. Muscle tissue. In: Fundamentals of Anatomy and Physiology, 10th edition. Eds. Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew. Upper Saddle River, New Jersey:Prentice Hall, Inc, 2015. Print.

Becker WM and Deamer DW. Energy from Chemical Bonds: The aerobic mode. In: The World of the Cell, 2nd Ed., The Benjamin Cummings Publishing Company, Inc, Redwood City , CA., pps. 275-313.

Wada H, Goto H, Hagiwara S, Yamamoto Y. Redox status of coenzyme Q10 is associated with chronological age. J Am Geriatr Soc. 2007 Jul;55(7):1141-2.

Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1646-50.

Fischer A, Onur S, Niklowitz P, Menke T, Laudes M, et al. Coenzyme Q10 status as a determinant of muscular strength in two independent cohorts. PLOS ONE. 2016;11(12): e0167124.

Sabbatinelli J, Orlando P, Galeazzi R, Silvestri S, Cirilli I, Marcheggiani F, Dludla PV, Giuliani A, Bonfigli AR, Mazzanti L, Olivieri F, Antonicelli R, Tiano L. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial. Nutrients. 2020 Apr 15;12(4):1098.

Agarwal A et al. Male Oxidative Stress Infertility (MOSI): Proposed terminology and clinical practice guidelines for management of idiopathic male infertility. World J Mens Health. 2019 Sep;37(3):296-312.

Lu J, Wang Z, Cao J, Chen Y, Dong Y. A novel and compact review on the role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2018 Aug 20;16(1):80.

Thakur AS, Littaru GP, Funahashi I, et al. Effect of Ubiquinol therapy on sperm parameters and serum testosterone levels in Oligoasthenozoospermic infertile men. J Clin Diagn Res. 2015;9(9):BC01-BC03.

Cakiroglu B, Eyyupoglu SE, Gozukucuk R, Uyanik BS. Ubiquinol effect on sperm parameters in subfertile men who have astheno-teratozoospermia with normal sperm concentration. Nephro Urol Mon. 2014;6(3):e16870.

Vaughan M S RA, Garcia-Smith R, Bisoffi M, Conn CA, Trujillo KA. Ubiquinol rescues simvastatin-suppression of mitochondrial content, function and metabolism: Implications for statin-induced rhabdomyolysis. Eur J Pharmacol. 2013 Jul 5;711(1-3):1-9.

Zlatohlavek L, Vrablik M, Grauova B, Motykova E, Ceska R. The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett. 2012;33 Suppl 2:98-101.

Fedacko J, Pella D, Fedackova P, Hänninen O, Tuomainen P, Jarcuska P, Lopuchovsky T, Jedlickova L, Merkovska L, Littarru GP. Coenzyme Q(10) and selenium in statin-associated myopathy treatment. Can J Physiol Pharmacol. 2013 Feb;91(2):165-70.

Langsjoen PH and Langsjoen AM. Comparison study of plasma coenzyme Q10 levels in healthy subjects
supplemented with ubiquinol versus ubiquinone. Clinical Pharmacol Drug Dev. 2014;3(1):13-17.

Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28.