What is Kaneka Ubiquinol™?

Kaneka Ubiquinol

 

Ubiquinol (“you-bik-win-all”) and ubiquinone (conventional CoQ10) are vitamin-like substances produced naturally in the body. They are two forms of the same vital nutrient (Co-Enzyme Q10 or CoQ10), but they function differently within the body.

Ubiquinone must first be converted to Ubiquinol in order to contribute to the production of cellular energy.1 This energy helps your heart and other vital organs function at optimal levels.* As you age, this conversion within your body becomes more difficult and less efficient. That is why many adults over the age of 40 choose to take a supplement made with Kaneka Ubiquinol™ daily.2

Kaneka Ubiquinol™ is the form of CoQ10 that your body can immediately use.3,4

Kaneka Ubiquinol™ is the pre-converted, advanced form of CoQ10. This means it’s ready for your body to use without any conversion, something that’s especially important for older adults or those with compromised health conditions that may have difficulty converting conventional CoQ10 to Ubiquinol.

Key Benefits of Ubiquinol

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Heart Health*

Ubiquinol promotes heart health by helping to provide the cellular energy needed to power the heart. Ubiquinol is critical in the production of ATP, the body’s primary fuel.1 This fuel is used for three basic yet critical heart functions:

  1. Contraction - to keep the heart pumping consistently
  2. Relaxation - to allow the heart to rest between beats
  3. Molecular Synthesis - to maintain heart health by building important cellular components.*

The energy demands of the heart are among the highest in the body. It takes energy for the ventricles of the heart to contract as they pump blood to the arteries, but it takes even more energy to relax the contracted muscle. The heart must generate large amounts of ATP constantly and consistently. Without enough ATP in the “energy pool”, the heart’s function would be compromised.

 
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Anti-Aging*

Our body is constantly creating and burning energy. These functions, in addition to the normal aging process, can generate unstable molecules called free radicals that seek out healthy cells and ultimately damage them.

This process of free radical damage is called oxidation. As we age, the negative effects of oxidation accumulate over time. Ubiquinol is one of the most powerful lipid soluble antioxidants known to scientists.5 Acting as an antioxidant, Ubiquinol can protect the cells in your body from free radical damage.*6

 
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Ubiquinol Depletion from Cholesterol-Lowering Medications (Statins)

Cholesterol is a fatty compound found in your blood and an important component of human health, but high levels of cholesterol have been linked with an increased risk of heart disease. To lower cholesterol levels, a statin medication may be prescribed by your doctor. Statin medications work by limiting the body’s production of cholesterol. In the process, they may also reduce the body’s natural production of Ubiquinol.7 Taking a Ubiquinol supplement each day is an excellent way of restoring Ubiquinol levels that may be reduced by cholesterol medications.*8,9

 

Why is Ubiquinol Better Than Conventional CoQ10?

BenefitUbiquinolConventional CoQ10

Required for 95% of your cellular energy production*19

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Superior bioavailability10-12

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Easily absorbed by the human body

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Optimally replenishes Ubiquinol in your body to protect and provide cellular energy10-15

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Predominant form of CoQ10 in a healthy body3,4,13,16-18

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Citations

  1. Beamer WM and Deamer DW. Energy from Chemical Bonds: The aerobic mode. In: The World of the Cell, 2nd Ed., The Benjamin Cummings Publishing Company, Inc, Redwood City , CA., pps. 275-313.
  2. Wada H, Goto H, Hagiwara S, Yamamoto Y. Redox status of coenzyme Q10 is associated with chronological age. J Am Geriatr Soc. 2007 Jul;55(7):1141-2.
  3. Mohr D, Bowry VW, Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta. 1992 Jun 26;1126(3):247-54.
  4. Tomasetti, M, Alleva R, Borghi B, Collins AR. In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. FASEB J. 2001 Jun;15(8):1425-7.
  5. Ernster L, Forsmark-Andrée P. Ubiquinol: an endogenous antioxidant in aerobic organisms. Clin Investig. 1993;71(8 Suppl):S60-5.
  6. Frei B, Kim MC, Ames BN. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci U S A. 1990 Jun;87(12):4879-83.
  7. Vaughan M S RA, Garcia-Smith R, Bisoffi M, Conn CA, Trujillo KA. Ubiquinol rescues simvastatin-suppression of mitochondrial content, function and metabolism: Implications for statin-induced rhabdomyolysis. Eur J Pharmacol. 2013 Jul 5;711(1-3):1-9.
  8. Zlatohlavek L, Vrablik M, Grauova B, Motykova E, Ceska R. The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett. 2012;33 Suppl 2:98-101.
  9. Fedacko J, Pella D, Fedackova P, Hänninen O, Tuomainen P, Jarcuska P, Lopuchovsky T, Jedlickova L, Merkovska L, Littarru GP. Coenzyme Q(10) and selenium in statin-associated myopathy treatment. Can J Physiol Pharmacol. 2013 Feb;91(2):165-70.
  10. Miles MV, Horn P, Milesc L, Tanga P, Steele P, DeGrauwa T. Bioequivalence of coenzyme Q10 from over-the-counter supplements. Nutr Res. 2002:22(8):919-929.
  11. Evans M, Baisley J, Barss S, Guthrie N. A randomized, double-blind trial on the bioavailability of two CoQ10 formulations. Journal of Functional Foods. 2009. 1: 65-73.
  12. Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88.
  13. Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28.
  14. Schmelzer C, Niklowitz P, Okun JG, Haas D, Menke T, Döring F. Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans. IUBMB Life. 2011 Jan;63(1):42-8.
  15. Shoko D, Fujii K, Kurihara T. The effect of the reduced form of coenzyme Q10 (Ubiquinol, Kaneka QH™ ) on QOL improvement in the elderly. J Clin Therap Med 2008; 24:233-238.
  16. Tang PH, Miles MV, DeGrauw A, Hershey A, Pesce A. HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma. Clin Chem. 2001 Feb;47(2):256-65.
  17. Yamashita S, Yamamoto Y. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Anal Biochem. 1997 Jul 15;250(1):66-73.
  18. Aberg F, Appelkvist EL, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys. 1992 Jun;295(2):230-4.
  19. Martini FH. Muscle tissue. In: Fundamentals of Anatomy and Physiology, 10th edition. Eds. Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew. Upper Saddle River, New Jersey:Prentice Hall, Inc, 2015. Print.
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